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My father needs chemo once every three weeks, but my mother cannot be left alone for long lengths of time and he is her primary care giver. I do not know when the worst part of the chemo occurs, and how much my mother can do with her dimentia, should i expect her to be able to do anything at all? She forgets to eat, she is overweight and weak legs. Refuses wheel chairs, and many assistive devices.

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I wouldn't expect that your mother can do much, and you certainly couldn't expect her to remember the things your dad needs. Chemotherapy often causes some memory issues ("chemo brain"), as well. You may want to consider hiring an in-home caregiver to go into the home and help them both.
Take care,
Carol
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